Neurobiology (Bp). Although the article does raise concerns about choline intake – this study points to greatest concern being present FOLLOWING a prostate cancer diagnosis, as choline utilization by cancer cells is abnormally high compared to normal cells. Often, the full name of supplements gets compressed into acronyms and this can get confusing (for example N-acetyl-L-Tyrosine becomes NALT, dimethylaminoethanol becomes DMAE, etc), especially when dealing with 2 supplements that have (at least, in the mind of the consumer) such similar functions or effects. Thanks for linking the article, very informative. As of now, this question is not easy to answer, and is still a very hot topic for debate. This choline source is about 40% choline by weight. What this means to you: As a choline replenishment agent, Alpha GPC is the more effective choice over CDP choline (but CDP has other tricks up its sleeve, as we will see later). Betaine intake was not associated with risk of lethal prostate cancer. Alpha GPC is a byproduct of phosphatidylcholine and is … Instead the precursor to Acetylcholine, Choline, must be obtained with through the diet or supplementation. Piracetam is a powerful nootropic that needs to be paired with an external choline source. When levels are low, thoughts can be sluggish, forming new memories or accessing old memories can be difficult, and you may experience “brain fog.”. The price difference is not too large, so the choice really comes down to personal preference. Taking alpha GPC could lead to improved vitality and increased strength as it helps muscles recover after exercise. There is an science article out reviewing GPC and free range choline and it’s increase in lethal prostate cancer and it is all bad news for GPC first then free change choline. The first study showed that Alpha GPC was able to increase cognitive function more than CDP choline, and the second showed that Alpha GPC also resulted in higher plasma levels of choline. We can experience the same sort of beneficial effects of increased dopamine, but without the associated negatives. I’d go with CDP Choline / Citicoline any day over GPC. Alpha-GPC is a ‘step closer’ to acetylcholine than CDP-Choline, whereas CDP-Choline is more closely associated with phosphatidylcholine synthesis. Is an intermediate step in the formation of phosphatidylcholine (PC) from choline (not a derivative – as Alpha GPC is). 1. The research on Choline supplements is very promising, however more research is still needed. Low concentrations of choline are associated with the development of fatty liver and liver damage (34, 35). Your email address will not be published. If you are NOT supplementing with PC, then the use of CDP choline might augment the production of PC  (PC is a very ‘healthful’ compound, with several important functions in the nervous system). (20). Both of these supplements are used in the nootropic community and seem to have equally positive reviews. Just like Alpha GPC, CDP choline has been shown to be well tolerated (side-effect free) and to exert a protective effect on neuron membranes as well as having a proven beneficial effect against alzheimers and other age-related cognitive diseases. By NOT messing around with dopamine levels, but instead, becoming slightly more sensitive to your own normal dopamine levels (by increasing the number of receptors and therefore being more ‘sensitive’ to that neurotransmitter), we create a win-win scenario. However, what is unclear to me is, if both CDP Choline, Cognizin or Alpha GPC lead to or aid in the production of Acetylcholine, why not just take Acetylcholine and cut to the chase? CDP-choline and Piracetam. I don’t have access to that article – but it would be interesting to see if they also make any distinction between types of choline and increased risk. We observed 695 events of lethal prostate cancer during 879,627 person-years. Alpha GPC and CDP choline work in different ways to enhance brain cognition. Alpha GPC is about 13% more expensive per 50 milligrams than DPC choline. CDP choline does not have this problem.. I am currently using an Alpha GPC / Prami stack and it works great. In addition, animal data suggest that choline intake may be beneficial to cognitive function and memory (36–39), and cytidinediphosphocholine—the intermediate produced in the conversion of choline to phosphatidylcholine—has been associated with improved memory in elderly persons in short-term randomized controlled trials (40). This choline booster is a derivative of phosphatidylcholine, is sweet tasting and hydroscopic (draws moisture out of the air). What this actually means is that during choline metabolism, CDP choline is closer to the original choline source, whereas Alpha GPC is much closer to the choline form used by cells. Both supplements are generally very well tolerated and side-effect free.? Alpha GPC is a byproduct of phosphatidylcholine, Alpha GPC was able to increase cognitive function, Piracetam, Aniracetam, Oxiracetam, Pramiracetam, and Noopept, Antal A, Kéri S, Bodis-Wollner I. L-alpha-glycerylphosphorylcholine enhances the amplitude of the pattern electroretinogram in rhesus monkeys. There really is no contest. Revisiting choline alphoscerate profile: a new, perspective, role in dementia? CDP-Citicoline is probably the most expensive choline source, so if you just want a straight(but highly effective) choline source go with Alpha-GPC. Benefits of Phosphatidylcholine. The pure choline content of the alpha GPC molecule is about 40%. One reason to go with Alpha GPC over CDP Choline is if you’re breastfeeding. A 10% voucher has been generated for you. 5. CDP choline increases dopamine receptor densities in the brain. Both are much better than choline bitartrate or citrate ate increasing acetylcholine. It seems logical to begin with the ‘alpha’ i.e. Since the acetylcholine molecule won’t penetrate this barrier, you wouldn’t be able to increase its levels in the brain directly, which means it wouldn’t be able to bind to cholinergic receptors on your neurons. Required fields are marked *. 2. Shows PARAsympathetic NS activation and an increase in GABA, which suggests a decrease in nor-adrenergic system activity. Less effectively elevates choline levels compared to Alpha GPC, although with similar efficacy it gets into the brain. Free UK Shipping on orders over £35 & £200 Globally. Your subscription could not be saved. This does not point to causation by any means. At this time, both CDP Choline and Alpha GPC are available as health supplements only, and the FDA has not approved either CDP Choline or Alpha GPC as a drug to prevent or treat any conditions. I think the take aways from this article are: Bitartrate is a precursor to acetylcholine. Join our newsletter and we'll let you know when we publish a new blog, release a new product or have an exclusive offer. 1993, Lopez CM, Govoni S, Battaini F, Bergamaschi S, Longoni A, Giaroni C, Trabucchi M. Effect of a new cognition enhancer, alpha-glycerylphosphorylcholine, on scopolamine-induced amnesia and brain acetylcholine. The obvious difference is that Alpha GPC is 40% choline by weight compared to CDP’s 18-19%; BUT CDP Choline makes up for it by also being a uridine supplement and not just a choline one; Alpha GPC has been proven to enhance the release of Growth … On the other hand, Alpha GPC is a byproduct of phosphatidylcholine instead of a precursor. Some users state that they find Alpha-GPC to act faster than CDP choline in … What I don’t understand is of Citicoline and Cognizin are the same thing, or (even ever so slightly) different. We'll also send you a 10% discount to use on your next order! CDP choline works as an intermediate to Acetylcholine, whereas Acetylcholine is a by-product in the breakdown process of Alpha GPC. Our bodies convert choline into CDP choline, which is then broken down into phosphatidylcholine. Choline supplements (particularly alpha GPC) are able to penetrate this barrier and then they can be made into acetylcholine once they are inside the brain. Since both Alpha GPC and CDP Choline are part of the same process, it is reasonable to ask which is then better for brain health? alpha GPC, so here we go: 1. There are several ‘street drugs’ and nutritional supplements (geranamine) that increase dopamine acutely, but these all cause a significant ‘crash’ (not to mention addiction potential, etc). 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